The Queen of Blood is rallying her monstrous army and preparing to march against the human race, and humanity's survival depends on Hellboy and Alice finding a supernatural army of their own. But the monsters Hellboy has killed over the years had powerful friends, and a vicious horde out for revenge has lured the pair into a trap. Now Hellboy and Alice's only hope for survival rests with three strange little birds, and their even stranger mistress.